ABSTRACT
The problem of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains highly relevant. Objective. To analyze clinical and laboratory characteristics of patients with moderate COVID-19. Materials and methods. This retrospective study included 132 patients with moderate COVID-19 treated in the Republican Immunological Center of the Republic of Dagestan between July and December 2020. The sample included 69 males and 63 females with a mean age of 52.4 ± 5.9 years. Results. The most common clinical manifestations included fever, fatigue, dry cough, and headache. Many participants had increased erythrocyte sedimentation rate (ESR);some patients had leukopenia, lymphopenia, and thrombocytopenia. Biochemical testing demonstrated mild alterations in the levels of C-reactive protein (CRP), ferritin, glucose, activity of liver enzymes (alanine aminotransferase, as-partate aminotransferase), fibrinogen, and D-dimer. These alterations were primarily observed in COVID-19 patients with CT-2 changes in their lung tissue. One-third of participant had lesions in lungs upon discharge. ECG changes (rhythm and conduction abnormalities) were detected in 15.9% of patients with concomitant cardiovascular diseases. Conclusion. COVID-19 patients with persistent clinical, laboratory, or radiological changes upon their discharge from hospital, as well patients with changes on ECG, require careful follow-up to assess their long-term outcomes. © 2021, Dynasty Publishing House. All rights reserved.
ABSTRACT
Objective: Analysis of COVID-19 clinical course based on mild and moderate symptoms of coronavirus infection in infants born to SARS-CoV-2 positive women, and evaluation of their adaptation in postnatal period. Materials and methods: A retrospective analysis of medical records of 280 pregnant women, who had confirmed clinical diagnosis of coronavirus infection with mild and moderate symptoms of COVID-19 and medical records of 267 infants born to women with SARS-CoV-2 infection, who are residents of the North Caucasian Federal District (the Republic of Ingushetia, Dagestan and North Ossetia–Alania). Results: The analysis of the course of the disease and major laboratory test results did not show significant differences between pregnant women with mild and moderate COVID-19 depending on the gestational age at the time of infection. High temperature, continuous cough, a loss or change to the sense of smell and taste, chest pain with breathing were the most common symptoms during three trimesters of pregnancy. Assessment of clinical laboratory results in pregnant women with COVID-10 and in infants born to patients with COVID-19 showed that biochemical blood test and a complete blood count play an important role in assessment of severity and prognosis of the disease. The data on the clinical manifestations of COVID-19 in pregnant women showed that immune responses induced by COVID-19 do not correlate with the severity of the disease. The analysis of infants’ health records showed that 12/267 (4.5%) newborns required admission to NICU due to low oxygen saturation levels, shortness of breath and tachypnea;7/267 (2.6%) newborns required mechanical ventilation. Conclusion: Most likely, the severity of COVID-19 in pregnant women depends not only and not so much on gestational age, but also on the presence of concomitant extragenital pathology and aggravated obstetric and gynecological anamnesis. Apparently, it is important that approach to management of pregnant women based on obstetric indications and maternal and fetal condition should individualized. Perinatal complications in newborns are likely due to impaired placental perfusion and/or thrombotic changes in mother, decreased barrier function and placental inflammatory changes. The issues discussed in this article confirm the high relevance of the problem of infants’ health status who were born to mother, who underwent COVID-19 at different terms of pregnancy, and this poses new challenges for identification of important features in monitoring, diagnosis, therapy and prevention of pathological conditions in newborns. © A group of authors, 2022.
ABSTRACT
The study deals with the clinical and laboratory manifestations of mild and moderate forms of COVID-19 depending on the gestational period in 69 pregnant women aged 18 to 41 (28.5 +/- 6.9), hospitalized with a "COVID-19" diagnosis. The patients under study exhibited no significant differences in clinical symptoms and main laboratory data, including coagulogram (p >0.05) throughout three trimesters of pregnancy. The severity of COVID-19 in pregnant women most likely depends on the presence of concomitant extragenital pathology and burdened gynecological history (pathology of previous pregnancies and childbirth) rather than on gestational period (pathology of previous pregnancies and childbirth), since more often these pathologies occurred in pregnant women with moderate COVID-19. The research showed that women in all three trimesters of pregnancy showed a significant increase (p <0.05) in C-reactive protein, a specific marker of inflammation, the findings, obtained in the 2nd and 3rd trimesters of pregnancy (26.7 +/- 21.97 and 32.7 +/- 26.5 mg/l) insignificantly (p1-3 = 0.056, p2-3 = 0.231) exceeded those, observed in the 1st trimester (14.8 +/- 26.9). Copyright (C) 2013 - All Rights Reserved - Pharmacophore